Which second-line tests should be performed when screening test results are inconclusive for pediatric chronic granulomatous disease (CGD)?

Updated: Aug 07, 2019
  • Author: Lawrence C Wolfe, MD; Chief Editor: Cameron K Tebbi, MD  more...
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Answer

Other tests

When screening results are inconclusive or when additional confirmation is required, other assays of phagocyte oxidative metabolism can be performed in research laboratories capable of studying phagocytes.

On Western blot analysis, failure to detect the p22, p47, or p67 products can be taken as evidence of autosomal recessive mutation in the corresponding gene.


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