What surgical prophylaxis is required for patients with antithrombin III (ATIII) deficiency?

Updated: Mar 04, 2020
  • Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD  more...
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Antithrombin III concentrates have been used in the perioperative period for surgical prophylaxis in patients with a known deficiency. Carefully determine the specific agent used, because the dosing of plasma-derived antithrombin widely differs from recombinant antithrombin.

Should antithrombin III concentrates not be available, fresh frozen plasma at a dose of 20 mL/kg can raise the antithrombin III level by approximately 20%.

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