What is the role of prothrombin time (PT) and activated partial thromboplastin time (aPTT) testing in the workup of antithrombin III (ATIII) deficiency?

Updated: Feb 10, 2018
  • Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD  more...
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Answer

These studies allow evaluation of the presence of inappropriate activation of the coagulation system.

aPTT is a useful screen for antiphospholipid (AP) antibody syndrome.

aPTT-mixing study may distinguish between AP antibody syndrome and disseminated intravascular coagulation (DIC). Advanced DIC may present with a persistently prolonged aPTT if fibrin degradation products inhibit fibrin generation or acquired deficiencies of coagulation factors are severe.


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