What is the role of antithrombin assays in the workup of antithrombin III (ATIII) deficiency?

Updated: Mar 04, 2020
  • Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD  more...
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Antithrombin III activity should be measured first.

If low, then antithrombin antigen is measured to look for mutations consistent with type II disease.

The single most commonly used test for antithrombin III assay is thrombin-heparin cofactor level.

Avoid measuring antithrombin III while the patient is on heparin or even warfarin.

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