What the risk factors for antithrombin III (ATIII) deficiency?

Updated: Mar 04, 2020
  • Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD  more...
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Other risk factors include the following:

  • Presence of a central line currently or in the past (This is an especially common risk factor for thrombosis in infants and small children, in whom the lumen of the vessel is small, and blood flow around the catheter is no longer laminar)

  • Medications known to be procoagulant or medications that nonspecifically impair protein synthesis (eg, L-asparaginase) [16]

  • Other diseases associated with procoagulant states (systemic lupus erythematosus [SLE], nephrotic syndrome, bone marrow transplantation, trauma)

  • Presence of a second pro-coagulant disorder (acquired or inherited)

  • Non-O ABO phenotype (This has been associated with increased thrombotic risk in other procoagulant conditions [prothrombin G20210A]; although little is known of the impact of ABO phenotype on more severe procoagulant conditions like antithrombin deficiency, the ABO phenotype should be documented.)

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