Which age groups have highest prevalence of antithrombin III (ATIII) deficiency?

Updated: Mar 04, 2020
  • Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD  more...
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Patients who are homozygous for gene defects often present in the neonatal period; individuals who are heterozygous for gene defects may remain asymptomatic well into middle age. A thrombotic challenge, such as placement of a central venous catheter or other vascular catheter, frequently unmask disease due to heterozygotic gene mutations. Individuals who have multiple catheter-related thrombotic events, or life/organ threatening events with no other risk factor, should be evaluated for an underlying procoagulant condition.

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