What is the morbidity associated with antithrombin III (ATIII) deficiency?

Updated: Mar 04, 2020
  • Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD  more...
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Answer

The incidence of thrombotic events is increased in patients with antithrombin III deficiency. In the hereditary form, the lifetime risk has been estimated to be 50-85%, whereas in other groups, the risk may be as low as 20%. [12, 10]

A study by Lenz et al in women with pregnancy-related complications and VTE found antithrombin III deficiency in just 3% of the group, although other thrombophilic risk factors were present. [13]

A literature review by Rhéaume et al indicated that women with asymptomatic antithrombin deficiency have a greater risk of pregnancy-associated VTE. The estimated odds ratio for VTE in these women, using pooled results from case-control studies, was 6.09. [14]


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