Which medications in the drug class Antidepressants are used in the treatment of Lumbosacral Facet Syndrome?

Updated: Nov 19, 2018
  • Author: Gerard A Malanga, MD; Chief Editor: Craig C Young, MD  more...
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Tricyclic antidepressants (TCAs) can be used as an adjunctive treatment for pain and sleep if they are taken at bedtime. The initial doses should be low, and subsequent doses can be slowly increased to minimize adverse effects.

Amitriptyline (Elavil)

Inhibits reuptake of serotonin and/or norepinephrine at presynaptic neuronal membrane, which increases the concentration in the CNS. Analgesic for certain chronic forms of pain.

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