What are the effects of androgen deficiency in Klinefelter syndrome?

Updated: Mar 23, 2020
  • Author: Germaine L Defendi, MD, MS, FAAP; Chief Editor: Luis O Rohena, MD, MS, FAAP, FACMG  more...
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Androgen deficiency causes the following:

  • Eunuchoid body proportions/female distribution of adipose tissue
  • Sparse or absent facial, axillary, pubic, or body hair
  • Gynecomastia 
  • Decreased muscle mass and strength
  • Decreased physical endurance
  • Small testes and penis
  • Diminished libido
  • Loss of functional seminiferous tubules and Sertoli cells, causing decrease in inhibin B levels (the hormone regulator of the follicle-stimulating hormone [FSH] level)
  • Altered hypothalamic-pituitary-gonadal axis in pubertal boys

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