What is the risk for recurrence of Down syndrome in mothers and siblings of a patient with Down syndrome?

Updated: Apr 30, 2018
  • Author: Gratias Tom Mundakel, MBBS, DCH; Chief Editor: Maria Descartes, MD  more...
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Answer

A previous history of trisomy can increase a woman’s risk for a recurrence. [99] If the couple has a child with trisomy 21, the risk of recurrence is about 1%. [100] The risk does not appear to be increased in siblings of affected individuals if it is confirmed to not be a translocation but rather full trisomy 21.


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