What is integrated prenatal screening of Down syndrome?

Updated: Apr 30, 2018
  • Author: Gratias Tom Mundakel, MBBS, DCH; Chief Editor: Maria Descartes, MD  more...
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Answer

With integrated screening, the pregnant woman undergoes a first-trimester screening (involving NT testing, PAPP-A, hCG) followed by the quadruple screen in the second trimester. This combined screening approach increases the detection rate of Down syndrome to 95%, with a false positive rate of only 5%.


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