What is the role of IgG measurement in the workup of Down syndrome?

Updated: May 18, 2020
  • Author: Gratias Tom Mundakel, MBBS, DCH; Chief Editor: Maria Descartes, MD  more...
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Measurement of immunoglobulin (Ig) G levels focuses on identifying deficiencies of subclasses 2 and 4. Decreased levels of IgG subclass 4 is significantly correlated with bacterial infections. These deficits in cellular immunity have also been documented in individuals with gingivitis and periodontal disease.

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