What are the possible immunologic complications of Down syndrome?

Updated: Apr 30, 2018
  • Author: Gratias Tom Mundakel, MBBS, DCH; Chief Editor: Maria Descartes, MD  more...
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Children are more prone to recurrent respiratory and systemic infections secondary to deficiencies in some immunoglobulin levels. B cells are reduced in number and function. Reduction in immune function has been shown to be secondary to overexpression of immunity-related genes on chromosome 21. [65] Immunoglobulin (Ig) A deficiency, as well as deficiencies of IgG subclasses, can be seen in individuals with Down syndrome. Individuals with Down syndrome are also more susceptible to autoimmune diseases, such as thyroid disease (hypothyroidism more often than hyperthyroidism), diabetes, and celiac disease. [58]

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