How does Down syndrome affect the immune system?

Updated: Apr 30, 2018
  • Author: Gratias Tom Mundakel, MBBS, DCH; Chief Editor: Maria Descartes, MD  more...
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Answer

Patients have about a 12-fold increased risk of infectious diseases, especially pneumonia, because of impaired cellular immunity. Chemotactic defects, as well as decreased immunoglobulin levels, have also been reported in studies of Down syndrome.


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