Which activity modifications are used in the treatment of carnitine deficiency?

Updated: Dec 13, 2019
  • Author: Fernando Scaglia, MD, FACMG; Chief Editor: Maria Descartes, MD  more...
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Answer

Once carnitine supplementation has been instituted for primary carnitine deficiency, cardiac function, strength, and growth improve significantly. No specific recommendations to limit physical activity are indicated if the cardiomyopathy has reverted.

Secondary carnitine deficiency caused by fatty acid oxidation disorders may require tempered or restricted activity in certain cases, including the following:

  • Conditions associated with increased risk for rhabdomyolysis and myoglobinuria (eg, carnitine palmitoyltransferase II [CPT-II] deficiency, very long-chain acyl-CoA dehydrogenase [VLCAD] deficiency)

  • Conditions in which a cardiomyopathy is present (eg, long-chain 3-hydroxyacyl-CoA dehydrogenase [LCHAD] deficiency, VLCAD deficiency)

Strenuous exercise or activity should be avoided, and frequent snacks and good hydration should be procured with physical activity.


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