Which histologic findings are characteristic of pediatric rhabdomyosarcoma (RMS)?

Updated: Mar 28, 2019
  • Author: Roshni Dasgupta, MD, MPH; Chief Editor: Eugene S Kim, MD, FACS, FAAP  more...
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Answer

The diagnosis of RMS should be confirmed through histologic evaluation of a tissue specimen, which may be attained by means of core, incisional, or excisional biopsy. The characteristic histologic finding of RMS is a small, blue, round cell (see the image below); this finding is pathognomonic for the disease. Cross-striations may be seen with light microscopy. Desmin, myogenin, myoD1, and muscle-specific actin are often seen in RMS. (For additional information, see Rhabdomyosarcoma.)

The histologic findings in rhabdomyosarcoma. The histologic findings in rhabdomyosarcoma.

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