Which clinical history findings are characteristic of pediatric rhabdomyosarcoma (RMS)?

Updated: Mar 28, 2019
  • Author: Roshni Dasgupta, MD, MPH; Chief Editor: Eugene S Kim, MD, FACS, FAAP  more...
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Answer

The clinical presentation of rhabdomyosarcoma (RMS) varies according to the site of presentation. Most patients, however, present with a painless mass, often discovered after minor trauma. Growth of the mass may impact adjacent structures, thus causing symptoms, including pain. When large, RMS may impinge on adjacent structures and lead to secondary problems such as bowel obstruction or respiratory distress.

Other symptoms are determined by location of the mass. Tumors originating in the head and neck may present as a mass or as signs and symptoms of central nervous system involvement due to intracranial extension of the tumor or infiltration of the cranial nerves, meninges, or brainstem. [22, 23]  RMS of the orbit may result in disconjugate gaze, whereas RMS of the uterus, cervix, or bladder may result in menorrhagia or metrorrhagia or difficulty voiding.


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