What is the prognosis of pediatric rhabdomyosarcoma (RMS)?

Updated: Mar 28, 2019
  • Author: Roshni Dasgupta, MD, MPH; Chief Editor: Eugene S Kim, MD, FACS, FAAP  more...
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Answer

With appropriate risk-adjusted treatment, the overall 5-year survival rate is in excess of 70%. The use of multimodal therapy and the long-term investigations by the IRSG have led to steady improvement in the prognosis for pediatric patients with RMS. IRS-IV determined that the failure-free survival rate and the overall 3-year survival rate are 77% and 86%, respectively, in patients without metastatic disease. In children with metastatic disease, despite current treatment, 5-year survival remains at approximately 30%.

Current emphasis is on stratification of therapy to provide local control with less impairment in functionality or cosmetics.


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