What is the role of MRI in the diagnosis of pediatric breast disorders?

Updated: Apr 01, 2019
  • Author: Harsh Grewal, MD, FACS, FAAP; Chief Editor: Robert K Minkes, MD, PhD  more...
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Answer

Answer

MRI with gadolinium-based enhancement has drawn interest as a modality for studying breast disease. [49] However, findings have been inconsistent. For example, age and menstrual cycle may affect parenchymal contrast medium enhancement. [50] In women with a high risk of breast cancer, breast MRI has high sensitivity (88%) but only moderate specificity (67%). [51]

In patients aged 25 years or older, guidelines recommend annual MRI as an adjunct to mammography in women at high risk, including the following [40] :

  • Women with a BRCA mutation
  • First-degree relatives of a BRCA carrier (untested)
  • Women with a lifetime risk of 20-25%
  • Women who received radiation to the chest between ages 10 and 30 years
  • Women with Li-Fraumeni syndrome, Cowden syndrome, or Bannayan-Riley-Ruvalcaba syndrome or first-degree relatives of individuals with those syndromes

The use of MRI in the pediatric and adolescent population has not been described.


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