What is the role of nitric oxide in the etiology of intussusception?

Updated: Dec 20, 2018
  • Author: A Alfred Chahine, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Experimental studies in animals showed that abnormal intestinal release of nitric oxide, an inhibitory neurotransmitter, caused relaxation of the ileocecal valve, predisposing to ileocecal intussusception. [8] Other studies have demonstrated that certain antibiotics cause ileal lymphoid hyperplasia and intestinal dysmotility, with resultant intussusception.


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