Which medications in the drug class Antacids are used in the treatment of Pediatric Gastroesophageal Reflux?

Updated: Mar 14, 2019
  • Author: Steven M Schwarz, MD, FAAP, FACN, AGAF; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Antacids

These agents are used as diagnostic tools to provide symptomatic relief in infants. Associated benefits include symptomatic alleviation of constipation (aluminium antacids) or loose stools (magnesium antacids).

Aluminum hydroxide (ALternaGEL)

Aluminum hydroxide increases gastric pH (>4) and inhibits the proteolytic activity of pepsin, reducing acid indigestion. Antacids can initially be used in mild cases. Aluminum hydroxide has no effect on the frequency of reflux but decreases its acidity.

Magnesium hydroxide (Phillips Milk of Magnesia)

Magnesium hydroxide is used as an antacid to relieve indigestion. It also causes the osmotic retention of fluid, which distends the colon and increases peristaltic activity, providing a laxative effect. This agent forms magnesium chloride in vivo after reacting with stomach hydrochloric acid.


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