Which medications in the drug class PPIs are used in the treatment of Pediatric Helicobacter Pylori Infection?

Updated: Nov 16, 2018
  • Author: Mutaz I Sultan, MBChB, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

PPIs

This class of drugs, which includes acid inhibitors more potent than the H2-receptor antagonists, blocks gastric acid secretion at the proton (Na+/H+ ATPase) pump, the final common pathway of secretion. This class is recommended as part of a drug regimen in symptomatic patients with H pylori infection. Similar to H2-receptor blockade, proton pump inhibitor (PPI) therapy alone does not eradicate H pylori infection; however, bacteriostatic activity against H pylori occurs.

Omeprazole (Prilosec)

Potent blocker of gastric acid. Best administered just before first meal of day. Enteric-coated granules in cap ensure appropriate bioavailability. For children unable to swallow intact cap, open and place granules in acidic substance (eg, apple sauce or apple juice), which is preferred to administering less bioavailable susp. Available as SR cap 10 or 20 mg and granules for PO susp 20 or 40 mg/packet.

Lansoprazole (Prevacid)

Potent blocker of gastric acid. Best administered just before first meal of day. Enteric-coated granules in the cap ensure appropriate bioavailability. For children unable to swallow intact cap, open and place granules in acidic substance (eg, apple sauce or apple juice), which is preferred to administering less bioavailable susp. Available as delayed-release cap 15 or 30 mg and granules for PO susp 15 mg or 30 mg/packet.


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