How is pediatric Helicobacter pylori (Hp) infection prevented?

Updated: Nov 16, 2018
  • Author: Mutaz I Sultan, MBChB, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

See the list below:

  • The mode of transmission of H pylori infection is not fully understood.

  • Data from epidemiologic studies suggest the following measures may help reduce transmission:

    • Policies that support the improvement of living conditions, particularly in developing countries

    • For all patients with chronic GI tract symptoms, appropriate referral for definitive diagnosis and treatment, which may help effect a cure and prevent exposure to family members and close contacts

    • Vaccines against H pylori infection: Several studies, performed with urease-based vaccines, showed limited immunogenicity and scarce efficacy in humans. The vaccine based on recombinant CagA–VacA–NAP proteins showed good immunogenicity and safety profile in phase I, but no subsequent efficacy trials were reported. No further results on clinical trials of H pylori vaccines were disclosed in the most recent years. Presently, there is no licensed anti– H pylori vaccine. [40]


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