What is the efficacy of vaccines against pediatric Helicobacter pylori (Hp) infection?

Updated: Nov 16, 2018
  • Author: Mutaz I Sultan, MBChB, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

A study by Zeng et al aimed to assess the efficacy, safety, and immunogenicity of a three-dose oral recombinant H pylori vaccine in children in China. The study tested the effectiveness of the vaccine on 4,446 children with a three-dose vaccination schedule. The study recorded 64 events of H pylori infection within the first year which resulted in a vaccine efficacy of 71.8%. 157 (7%) participants in the vaccine group and 161 (7%) participants in the placebo group reported at least one adverse reaction that were reported as mild. [38, 39]


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