Which medications in the drug class Corticosteroids are used in the treatment of Pediatric Crohn Disease?

Updated: Oct 23, 2018
  • Author: Andrew B Grossman, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Corticosteroids

Corticosteroids are used to treat active moderate-to-severe disease. They are not indicated for maintenance therapy. Budesonide is available in ileal controlled-release form and is used for the treatment of ileal or right-side colonic disease.

Prednisone

Prednisone exercises its anti-inflammatory effects through decreased capillary permeability, impaired neutrophil chemotaxis, release of anti-inflammatory cytokines, decreased production of eicosanoids, and stabilization of the lysosomal membrane.

Methylprednisolone (Medrol, Solu-Medrol)

Methylprednisolone exerts its anti-inflammatory effects by means of decreased capillary permeability, impaired neutrophil chemotaxis, release of anti-inflammatory cytokines, decreased production of eicosanoids, and stabilization of the lysosomal membrane.

Budesonide (Entocort EC)

Budesonide exerts its anti-inflammatory effects by means of decreased capillary permeability, impaired neutrophil chemotaxis, release of anti-inflammatory cytokines, decreased production of eicosanoids, and stabilization of the lysosomal membrane.

Hydrocortisone (Cortenema, Anusol-HC, Anucort HC, Anu-med HC, Proctosol-HC)

Hydrocortisone is a rectally administered corticosteroid similar to the intravenous (IV) and oral corticosteroids; significant amounts of corticosteroids can be absorbed systemically when these agents are administered via an enema or suppository. Various products containing hydrocortisone are available for rectal use. This agent is useful for treating distal colonic disease.


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