Which medications in the drug class Immunosuppressants are used in the treatment of Pediatric Crohn Disease?

Updated: Oct 23, 2018
  • Author: Andrew B Grossman, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Immunosuppressants

Immunosuppressive agents are used to treat moderate-to-severe Crohn disease, to treat steroid-dependent or steroid-refractory disease, and to maintain remission.

6-Mercaptopurine (Purinethol)

6-Mercaptopurine (6-MP) and its prodrug, azathioprine, are purine analogues that interfere with protein synthesis and nucleic acid metabolism. 6-MP has a cytotoxic effect on lymphoid cells. The onset of action is delayed for 2-3 months.

Azathioprine (Imuran, Azasan)

Azathioprine antagonizes purine metabolism and inhibits synthesis of DNA, RNA, and proteins. It may decrease the proliferation of immune cells, which lowers autoimmune activity.

Methotrexate (Trexall, Rheumatrex)

Methotrexate impairs DNA synthesis, induces apoptosis, and reduces production of interleukin (IL)-1. It is used for treatment of moderate-to-severe disease and maintenance of remission. The onset of action is delayed.


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