Which medications in the drug class Monoclonal Antibodies are used in the treatment of Pediatric Crohn Disease?

Updated: Oct 23, 2018
  • Author: Andrew B Grossman, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Monoclonal Antibodies

Biologic agents are used in the treatment of active Crohn disease or fistulizing disease that is unresponsive to other medical therapy.

Infliximab (Inflectra, Remicade)

Infliximab is a chimeric immunoglobulin G1 kappa (IgG1κ) monoclonal antibody that neutralizes cytokine tumor necrosis factor (TNF)-α and inhibits its binding to TNF-α receptors. It reduces infiltration of inflammatory cells and TNF-α production in inflamed areas.

Adalimumab (Humira)

Adalimumab is a recombinant human IgG1 monoclonal antibody that is specific for human TNF. It binds specifically to TNF-α and blocks interaction with p55 and p75 cell-surface TNF receptors. It is indicated for children older than 6 years with moderately to severely active Crohn disease who have had an inadequate response to corticosteroids or immunomodulators (eg, azathioprine, 6-mercaptopurine, methotrexate).


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