What is the top-down approach to therapy for pediatric Crohn disease?

Updated: Oct 23, 2018
  • Author: Andrew B Grossman, MD; Chief Editor: Carmen Cuffari, MD  more...
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Some adult data support the use of biologic therapy earlier in the course of disease (ie, a top-down approach) as a more effective treatment method. [17] A small, retrospective pediatric trial also supported the use of a top-down approach, but prospective pediatric data are needed. [18]

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