Which histologic findings may help differentiate ulcerative colitis (UC) from pediatric Crohn disease?

Updated: Oct 23, 2018
  • Author: Andrew B Grossman, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

The presence of granulomas may be helpful in differentiating between UC and Crohn disease (see the image below), but granulomas are present in only about 30% of biopsy specimens obtained from patients with Crohn disease.

Colonic granuloma in patient with Crohn disease. H Colonic granuloma in patient with Crohn disease. Hematoxylin-eosin staining. Image courtesy of Dr E Ruchelli.

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