Which intestinal biopsy findings indicate pediatric Crohn disease?

Updated: Oct 23, 2018
  • Author: Andrew B Grossman, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

The microscopic findings in intestinal biopsy samples from pediatric patients with Crohn disease consist of edema, inflammation (mononuclear and polymorphonuclear), cryptitis and crypt abscesses, architectural crypt changes, and transmural extension of the inflammation (see the image below).

Histologic features of chronic colitis with crypt Histologic features of chronic colitis with crypt atrophy and branching and lymphocytic infiltrate. Hematoxylin-eosin staining. Image courtesy of Dr E Ruchelli.

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