What is the role of serologic testing in the diagnosis of pediatric Crohn disease?

Updated: Oct 23, 2018
  • Author: Andrew B Grossman, MD; Chief Editor: Carmen Cuffari, MD  more...
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Serologic testing for inflammatory bowel disease (IBD) is available. Immunoglobulin A (IgA) and immunoglobulin G (IgG) antibodies to anti– Saccharomyces cerevisiae (ASCA) have been associated with Crohn disease, whereas perinuclear antineutrophil cytoplasmic antibody (p-ANCA) has been associated with ulcerative colitis (UC).

Although these tests might assist in differentiating between Crohn disease and UC, they are not good screening tests. In a retrospective review, serologic screening that included ASCA, pANCA, and antibody to Escherichia coli outer membrane porin (anti-OmpC) demonstrated a sensitivity of 60%, a specificity of 91%, and a positive predictive value of 60%. [15]

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