Which lab test results indicate pediatric Crohn disease?

Updated: Oct 23, 2018
  • Author: Andrew B Grossman, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Laboratory data for Crohn disease are nonspecific, as follows:

  • The CBC may show hypochromic microcytic anemia, from iron deficiency due to GI blood loss, or normocytic anemia of chronic disease

  • levels of acute-phase reactants (ESR and CRP) are often elevated in patients with Crohn disease but may be normal

  • Hypoalbuminemia is common

  • Additional common deficiencies include iron and micronutrients (eg, folic acid, vitamin B-12, serum iron, total iron binding capacity, calcium, and magnesium)

  • Stool studies should be obtained to rule out bacterial or parasitic infection

  • Excretion of fecal calprotectin is increased with colorectal inflammation [1] ; on ELISA, the cutoff level is 50 µg/g feces.


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