Which medications in the drug class Anti-inflammatory Agents are used in the treatment of Colitis?

Updated: Jan 04, 2019
  • Author: David A Piccoli, MD; Chief Editor: Carmen Cuffari, MD  more...
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Anti-inflammatory Agents

Corticosteroids and 5-aminosalicylic acid (5-ASA) derivatives are used to treat ulcerative colitis (UC).

Sulfasalazine (Azulfidine, Azulfidine EN-tabs)

Sulfasalazine is a sulfonamide derivative conjugate of 5-ASA. It serves as a carrier for 5-ASA. Sulfasalazine is useful in the management of UC and acts locally in the colon to decrease the inflammatory response and systemically inhibit prostaglandin synthesis.

Mesalamine (5-ASA, Asacol, Pentasa, Rowasa, Lialda)

Mesalamine is used for mild-to-moderate UC. It is the active component of sulfasalazine. Mesalamine affects chemical mediators of the inflammatory response, particularly prostaglandins and leukotrienes. The usual course of therapy in adults lasts 3-6 weeks. Some patients may need concurrent rectal and oral therapy. Oral products are formulated to release slowly throughout the gastrointestinal (GI) tract.

Hydrocortisone (Solu-Cortef, Cortef)

Hydrocortisone decreases inflammation by suppressing the migration of polymorphonuclear leukocytes (PMNs) and reversing increased capillary permeability.

Methylprednisolone (Medrol, Solu-Medrol, Depo-Medrol)

Methylprednisolone decreases inflammation by suppressing the migration of PMNs and reversing increased capillary permeability.

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