Which medications are used in the treatment toxic megacolon in colitis?

Updated: Oct 02, 2017
  • Author: David A Piccoli, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Begin a combination of broad-spectrum IV antibiotics, such as ampicillin (200 mg/kg/day), gentamicin (5-7.5 mg/kg/day), and clindamycin (40 mg/kg/day). Alternate therapy may include either ampicillin-sulbactam or cefoxitin in combination with gentamicin.


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