What are the risks factors for developing adenocarcinoma in ulcerative colitis (UC)?

Updated: Oct 02, 2017
  • Author: David A Piccoli, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

The risk factors for developing adenocarcinoma in UC are the duration and extent of disease. After the first decade of disease, the risk of development of colon cancer increases rapidly; thus, surveillance colonoscopy should be performed annually or biannually after 8-10 years of colonic disease. Colectomy should be performed if there is finding of high-grade dysplasia. [10]

The course of UC is marked by remissions and exacerbations. Most patients respond initially to medical treatment, and many children with mild manifestations stay in remission on prophylactic therapy with 5-aminosalicylic acid (5-ASA). Despite complications, most children with CD lead active lives, despite intermittent symptom flare-ups.


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