Which lab studies are performed in the workup of cholestasis?

Updated: Aug 09, 2017
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Serum bilirubin levels are elevated in virtually all patients with cholestasis.

Total serum bile salt concentration levels are elevated in virtually all cholestatic diseases.

Qualitative serum and urine bile acids by mass spectroscopy are used to identify genetically determined errors in bile acid synthesis.

The total serum cholesterol level is elevated in virtually all obstructive cholestatic diseases, whereas the high-density lipoprotein (HDL) level is within the reference range or low. Total cholesterol is within the reference range in certain hepatocellular cholestatic diseases, whereas the HDL level is within the reference range or low.

Serum lipoprotein-X levels are elevated in virtually all obstructive cholestatic diseases.

Serum alkaline phosphatase levels, serum 5'-nucleotidase levels, and serum gamma-glutamyl transferase (GGT) levels are elevated in virtually all obstructive cholestatic diseases and most hepatocellular cholestatic diseases.


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