What are the primary pathophysiologic effects of cholestasis?

Updated: Aug 09, 2017
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: Carmen Cuffari, MD  more...
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The effects of cholestasis are profound and widespread. Although the principal effects involve the function of the liver and intestine, secondary effects can involve every organ system. The primary effects are bile retention, regurgitation of bile into serum, and reduction in bile delivery to the intestine. These result in secondary effects that lead to worsening liver disease and systemic illness.

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