What is the pathophysiology of obstructive cholestasis?

Updated: Aug 09, 2017
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Obstructive cholestasis is usually the result of physical obstruction of the biliary system at the level of the extrahepatic bile ducts. However, obstruction or paucity of small bile ducts can result in functional obstruction of the entire biliary system. This may be the mechanism involved in the cholestasis observed in Alagille syndrome, which is associated with heart, skeleton, eye, kidney, and facial manifestations. The prognosis mainly depends on the severity of the liver and heart diseases.


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