Which medications in the drug class Penicillins are used in the treatment of Pediatric Appendicitis?

Updated: Oct 25, 2018
  • Author: Adam C Alder, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Penicillins

The penicillins are bactericidal antibiotics that work against sensitive organisms at adequate concentrations and inhibit the biosynthesis of cell wall mucopeptide. Examples of extended-spectrum penicillins include ticarcillin and clavulanate (Timentin) and ampicillin and sulbactam (Unasyn).

Ampicillin (Marcillin, Omnipen, Polycillin, Principen)

Ampicillin is a beta-lactam antibiotic with activity against some gram-positive and gram-negative organisms. It inhibits bacterial cell wall synthesis during active multiplication.

Ampicillin/sulbactam (Unasyn)

A combination of ampicillin with a beta-lactamase inhibitor, this agent has activity against some gram-positive organisms, gram-negative organisms (nonpseudomonal species), and anaerobic bacteria.

Piperacillin/tazobactam (Zosyn)

A combination of a beta-lactamase inhibitor with piperacillin, this agent has activity against some gram-positive organisms, gram-negative organisms, and anaerobic bacteria. It inhibits biosynthesis of bacterial cell wall mucopeptide and is effective during the stage of active multiplication.

Ticarcillin and clavulanate potassium (Timentin)

This combination of an antipseudomonal penicillin plus a beta-lactamase inhibitor provides coverage against most gram-positive and gram-negative organisms and most anaerobes. It inhibits biosynthesis of cell wall mucopeptide and is effective during the stage of active growth.

Imipenem and cilastatin (Primaxin)

This combination agent is indicated for treatment of multiple organism infections in which other agents do not have wide-spectrum coverage or are contraindicated because of potential for toxicity.


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