Which medications in the drug class Aminoglycosides are used in the treatment of Pediatric Appendicitis?

Updated: Oct 25, 2018
  • Author: Adam C Alder, MD; Chief Editor: Carmen Cuffari, MD  more...
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Answer

Aminoglycosides

Aminoglycosides are bactericidal antibiotics used to primarily treat gram-negative infections. They interfere with bacterial protein synthesis by binding to 30S and 50S ribosomal subunits.

Gentamicin (Garamycin, Gentacidin)

Gentamicin is an aminoglycoside antibiotic with activity against gram-negative bacteria, including Pseudomonas species. It is synergistic with beta-lactams against enterococci. Gentamicin interferes with bacterial protein synthesis by binding to 30S and 50S ribosomal subunits. Dosing regimens are numerous; adjust the dose based on creatinine clearance and changes in volume of distribution. Gentamicin may be administered intravenously or intramuscularly.


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