Which medications in the drug class Glucocorticoids are used in the treatment of Thyroid Storm?

Updated: Mar 16, 2020
  • Author: Madhusmita Misra, MD, MPH; Chief Editor: Robert P Hoffman, MD  more...
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These agents block conversion of T4 to T3. The use of corticosteroids has been associated with improved survival. Stress doses are required to replace accelerated production and degradation of cortisol induced by TH. If corticosteroids are not administered, acute glucocorticoid deficiency hypothetically could occur because demand may outpace production.

Hydrocortisone (Solu-Cortef)

Hydrocortisone provides mineralocorticoid activity and glucocorticoid effects and may help ameliorate decreased adrenal reserve. It reduces the conversion of T4 to T3.

Dexamethasone (Decadron)

Dexamethasone elicits glucocorticoid effects; however, hydrocortisone is preferred in thyroid storm.

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