What is the role of glucocorticoids in thyroid storm treatment?

Updated: Mar 16, 2020
  • Author: Madhusmita Misra, MD, MPH; Chief Editor: Robert P Hoffman, MD  more...
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Answer

Glucocorticoids

  • Administer glucocorticoids to decrease peripheral conversion of T4 to T3. This may also be useful in preventing relative adrenal insufficiency due to hyperthyroidism and improving vasomotor symptoms. Hydrocortisone is administered intravenously at a dose of 100 mg every 8 hours or dexamethasone at a dose of 1-2 mg every 6 hours. 

  • Dosing of glucocorticoids for thyroid storm in children:

    • Hydrocortisone: 5 mg/kg (up to 100 mg) intravenously every 6-8 hours

    • Dexamethasone: 0.1-0.2 mg/kg per day divided every 6-8 hours


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