What is the role of thyroid tests in the workup of precocious puberty?

Updated: Nov 30, 2020
  • Author: Paul B Kaplowitz, MD, PhD; Chief Editor: Robert P Hoffman, MD  more...
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Answer

Thyroid tests are not a routine requirement in the evaluation of precocious puberty. Mild to moderate hypothyroidism does not lead to early puberty, and severe hypothyroidism only rarely does, in a phenomenon known as Van Wyk-Grumbach syndrome. Major clues suggesting severe hypothyroidism include growth arrest instead of growth acceleration, goiter, and symptoms of thyroid hormone deficiency (fatigue, cold intolerance).


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