Which medications in the drug class IGFs are used in the treatment of Hyposomatotropism (Growth Hormone Deficiency)?

Updated: Jan 24, 2019
  • Author: Sunil Kumar Sinha, MD; Chief Editor: Robert P Hoffman, MD  more...
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These agents are indicated for long-term treatment of severe primary IGF deficiency.

Mecasermin (Increlex), mecasermin rinfabate (Iplex)

Recombinant IGF-1 and IGF-1 with equimolar binding protein-3 (IGFBP-3). Indicated for long-term treatment of growth failure in children with severe primary IGF-1 deficiency (ie, basal IGF-1 and height standard deviation scores of -3 or lower, normal or elevated GH value). IGF-1 essential for normal growth of children's bones, cartilage, and organs, as it stimulates glucose, fatty acids, and amino acid uptake into tissues. IGF-1 is principal hormone for statural growth and directly mediates GH effect. Primary IGF deficiency characterized by lack of IGF-1 production despite normal or elevated GH concentrations.

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