What is the role of IGFBPs RIAs in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

Updated: Jan 24, 2019
  • Author: Sunil Kumar Sinha, MD; Chief Editor: Robert P Hoffman, MD  more...
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Answer

To diagnose GHD, assaying the serum IGFBP-3 concentration may be superior to measuring the free IGF-1 concentration for at least 2 reasons. First, IGFBP-3 levels vary less with nutritional status than free IGF-1 values. Second, serum IGFBP-3 levels, even in young children, are typically more than 500 mg/mL; therefore, the detection of low levels is feasible.


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