What are the possible limitations of serum GH concentration measurements to diagnose hyposomatotropism (growth hormone deficiency [GHD])?

Updated: Jan 24, 2019
  • Author: Sunil Kumar Sinha, MD; Chief Editor: Robert P Hoffman, MD  more...
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Answer

Basal, oscillating, and pulsatile GH inputs and the wide range of intrasubject and intersubject variance in GH pharmacokinetics negate the assumption of a uniform relationship between GH secretion and serum GH concentration. Because of this, peak GH concentration is an oversimplified outcome of GH testing. Bright and colleagues postulated that serum GH concentrations reflect multiple components of GH input and that a composite pharmacokinetic model that accounts for pulsatile (infused), basal, and oscillatory components is required to accurately estimate each individual's pharmacokinetic parameters. [52]  Ongoing research may aid in applying these complex mathematical models to daily practice. [53, 54]


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