What are the diagnostic criteria for hyposomatotropism (growth hormone deficiency [GHD])?

Updated: Jan 24, 2019
  • Author: Sunil Kumar Sinha, MD; Chief Editor: Robert P Hoffman, MD  more...
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Random testing of serum GH concentrations is of no use in establishing the diagnosis of GHD. Provocative GH testing is not the current criteria standard. Current diagnostic criteria include the following:

  • Growth-velocity Z score below -2, evidence of certain genetic mutations (eg, GH1 deletion; IGF1 deletion; mutations involving SHOX, PIT1, PROP1, Turner syndrome, and Prader-Willi syndrome) [51]

  • Predicted adult height (Bayley-Pinneau value more than 1.5 standard deviations below the calculated midparental target height)

  • Serum-free or total IGF-1 Z score below -2 (ie, more than 2 standard deviations below the mean for the patient's age, sex, and Tanner stage)

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