What is included in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

Updated: Jan 24, 2019
  • Author: Sunil Kumar Sinha, MD; Chief Editor: Robert P Hoffman, MD  more...
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Answer

The diagnosis of growth hormone (GH) deficiency (GHD), or hyposomatotropism, remains controversial. The Growth Hormone Research Society [48, 49, 50] convened an international workshop of acknowledged authorities to address this issue. [48]  The diagnosis of GHD is a multifaceted process requiring comprehensive clinical and auxologic assessment combined with biochemical testing of the GH-insulinlike growth factor (IGF) axis and radiologic evaluation. Biochemical testing of the GH-IGF axis includes radioimmunoassays (RIAs) of GH, IGF, and insulinlike growth factor binding proteins (IGFBPs)

Regarding clinical and auxologic assessment, history taking and physical examination are the most useful diagnostic tools because the diagnosis of GHD rests on clinical judgment. The foundation for the diagnosis of GHD is careful, serial documentation of the patient's height and a determination of height velocity.

In the absence of other evidence of pit-hGH secretory dysfunction, testing for GH secretion is typically unnecessary.


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