Which medications in the drug class Diuretics are used in the treatment of Hypophosphatemic Rickets?

Updated: May 18, 2020
  • Author: James CM Chan, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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Thiazides are anticalciuric, an effect that can assist in counteracting the tendency for bone calcium loss.

Hydrochlorothiazide (Microzide)

Hydrochlorothiazide is a well-known diuretic with antihypertensive action. It inhibits reabsorption of sodium in distal tubules, causing increased excretion of sodium and water, as well as of potassium and hydrogen ions. Hydrochlorothiazide is not metabolized and is rapidly excreted in the urine.


Hypokalemia is a hazard when kaliuretic-effect thiazides are used; this danger that can be counteracted with the use of a second diuretic. Amiloride has a well-characterized antikaliuretic effect. Often used together with thiazides for its synergistic antihypertensive effects, amiloride has the benefit of decreasing potassium loss. Thus, it is a useful adjunct in the treatment of patients with familial X-linked hypophosphatemia with thiazides, in whom hypokalemia is a risk.

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