What is the role of imaging studies in the diagnosis of hypophosphatemic rickets?

Updated: May 18, 2020
  • Author: James CM Chan, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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Answer

In all cases of rickets, the study of choice is radiography of the wrists, knees, ankles, and long bones. However, no pathognomonic sign on radiographs distinguishes hypophosphatemic rickets from any other etiology.

On the other hand, a study by Lempicki et al indicated that in hypophosphatemic rickets, magnetic resonance imaging (MRI) reveals characteristics of the knee—including maximum physial widening and transverse degree of widening—that correlate with alkaline phosphatase levels. [28]


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